
MOTS-C
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MOTS-C Research Overview
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome, in the 12S rRNA region — one of a small group of mitochondrial-derived peptides identified since 2015. MOTS-C is supplied for qualified in-vitro laboratory research and analytical use only.
Compound profile
- Compound class: Mitochondrial-derived peptide (MDP)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 aa)
- Molecular weight: ≈ 2174.6 g/mol
- CAS number: 1627580-64-6
- Form: Lyophilized powder in a sealed vial
- Testing: Third-party HPLC purity and identity, batch-matched COA
Research context
MOTS-c research centers on metabolic regulation: AMPK activation, glucose uptake in skeletal muscle, insulin sensitivity and the response to metabolic and oxidative stress. Studies have also examined its translocation to the nucleus under stress and its links to exercise capacity and aging in animal models.
Storage and handling
Store unopened lyophilized vials sealed and protected from light — at −20 °C for long-term storage, or 2–8 °C for short-term use. Once reconstituted, keep refrigerated at 2–8 °C, minimize freeze–thaw cycles and rely on your laboratory’s own validated stability data.
Quality and documentation
Every lot is third-party tested, and the Certificate of Analysis is matched to the exact batch you receive — look it up any time on the COA page. Browse more Mitochondrial & Cellular Energy Research, or see related compounds: ŚŚ-31, NAD+ (Nicotinamide Adenine Dinucleotide).
Research Use Only Notice: Not for human consumption, not for veterinary use, not for clinical or diagnostic use, and not intended as a drug, food, dietary supplement, cosmetic, or household product. Purchaser is responsible for confirming lawful use, handling requirements, and regulatory status before purchase or use.